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Clinicopathological and prognostic value of CD24 expression in breast cancer: a meta-analysis

Clinicopathological and prognostic value of CD24 expression in breast cancer: a meta-analysis

Int J Biol Markers 2017; 32(2): e182 - e189

Article Type: REVIEW

DOI:10.5301/jbm.5000254

Authors

Gao Liu, Guo-Xing Liu, Yu Fang, Zhen-Yu Cao, Hui-Hui Du, Jie Fu, Ke Qian

Abstract

Background

A number of studies have been conducted to explore the relationship between CD24 expression and the prognosis of breast cancer; however, the results remain inconsistent. Therefore, we performed this meta-analysis to clarify the impact of CD24 expression on clinicopathological features and prognosis of breast cancer.

Methods

A comprehensive literature search for relevant studies was performed, and statistical analysis was conducted using Stata software.

Results

Twenty studies, including 5,179 cases, were included in this meta-analysis. The pooled analysis indicated that CD24 expression was associated with lymph node invasion (odds ratio [OR] = 0.68, for negative vs. positive, 95% confidence interval [95% CI], 0.53-0.87, p = 0.002) and TNM stage (OR = 0.63, for I + II vs. III + IV, 95% CI, 0.49-0.81, p<0.001). The prognosis analysis also suggested CD24 overexpression indicated a poorer 5-year overall survival (OS) rate (relative risk ratio [RR] = 0.93, 95% CI, 0.86-0.99, p = 0.03) and 5-year disease-free survival (DFS) rate (RR = 0.90, 95% CI, 0.83-0.98, p = 0.02). However, CD24 expression had no correlation with tumor size, tumor grade, distance metastasis, estrogen receptor (ER) status, progesterone receptor (PR) status, or HER2 status.

Conclusions

Our results suggest that higher CD24 expression is significantly associated with lower OS rate, lower DFS rate and some clinicopathological factors such as lymph node invasion and TNM stage. This meta-analysis suggested that CD24 is an efficient prognostic factor in breast cancer.

Article History

Disclosures

Financial support: No grants or fundings have been received for this study.
Conflict of interest: None of the authors has any financial interest related to this study to disclose.

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Authors

Affiliations

  • Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha - PR China

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