Advertisement

Des-gamma-carboxy prothrombin in hepatocellular cancer patients waiting for liver transplant: a systematic review and meta-analysis

Abstract

Background

The use of des-gamma-carboxy prothrombin (DCP) as a predictor of the risk of recurrence of hepatocellular cancer (HCC) after liver transplant (LT) has recently gained interest, especially in view of the recent extension of the eligibility criteria of these patients for LT. The aim of the present study is to look into this important matter based on a systematic review and meta-analysis.

Methods

A systematic literature review about the role of DCP in the specific setting of LT for HCC has been conducted.

Results

Three selected studies, which showed a high rate of homogeneity (I2 = 0.0%), confirmed that the tumor marker DCP is a useful predictive factor, indicating a 5-fold increased risk for HCC recurrence after LT (p<0.001).

Conclusions

The meta-analysis enabled us to underline the importance of DCP in the refinement of the eligibility criteria of HCC patients for LT. This information, based on Japanese studies performed in the setting of living-donor LT only, needs further validation in the Western world both in the setting of post-mortem and living-donor LT.

Int J Biol Markers 2017; 32(4): e370 - e374

Article Type: REVIEW

DOI:10.5301/ijbm.5000276

Authors

Quirino Lai, Samuele Iesari, Giovanni Battista Levi Sandri, Jan Lerut

Article History

Disclosures

Financial support: None.
Conflict of interest: The authors have no conflicts of interest to declare in relation to the content of the paper.

This article is available as full text PDF.

  • If you are a Subscriber, please log in now.

  • Article price: Eur 36,00
  • You will be granted access to the article for 72 hours and you will be able to download any format (PDF or ePUB). The article will be available in your login area under "My PayPerView". You will need to register a new account (unless you already own an account with this journal), and you will be guided through our online shop. Online purchases are paid by Credit Card through PayPal.
  • If you are not a Subscriber you may:
  • Subscribe to this journal
  • Unlimited access to all our archives, 24 hour a day, every day of the week.

Authors

Affiliations

  •  Starzl Abdominal Transplant Unit, University Hospitals Saint Luc, Université Catholique Louvain, Brussels - Belgium
  •  Transplant Unit, Department of Surgery, La Sapienza University, Rome - Italy

Article usage statistics

The blue line displays unique views in the time frame indicated.
The yellow line displays unique downloads.
Views and downloads are counted only once per session.

No supplementary material is available for this article.