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MUC1 rs4072037 polymorphism is associated with decreased risk of gastric cancer: a meta-analysis

Abstract

Background

Several studies have recently investigated the association between mucin 1 (MUC1) rs4072037 polymorphism and gastric cancer (GC) risk, but with conflicting results. The aim of this meta-analysis was to evaluate the association between MUC1 rs4072037 polymorphism and GC risk.

Methods

A comprehensive database search of PubMed, Elsevier, Embase and China National Knowledge Infrastructure (CNKI) databases was performed to identify relevant studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of any association.

Results

A total of 12 papers containing 18 studies were included in this meta-analysis, involving 12,373 cases and 15,008 controls. Our data suggested that rs4072037 polymorphism was associated with a decreased risk of GC. Stratification analyses of ethnicity indicated that rs4072037 decreased the risk of GC among white populations, but no significant relationship was observed among Asian populations. No significant associations were observed in subgroups of Lauren classification (intestinal or diffuse) and anatomical classification (cardia or non-cardia).

Conclusions

In conclusion, this meta-analysis suggested that rs4245739 polymorphism in the MUC1 gene may play a pivotal role in the pathogenesis of GC, especially for white populations.

Int J Biol Markers 2017; 32(3): e284 - e290

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/ijbm.5000270

Authors

Yu Ye, Chong Yang, Lei Xu, Dilong Fang

Article History

Disclosures

Financial support: No grants or funding have been received for this study.
Conflict of interest: The authors declare they have no conflicts of interest.

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Authors

Affiliations

  •  Department of General Surgery, Hang Zhou Red Cross Hospital, Hangzhou, Zhejiang - PR China
  •  Department of Digestion, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang - PR China

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