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The role of serum neuron-specific enolase in patients with prostate cancer: a systematic review of the recent literature

Abstract

In this systematic review, we evaluated the value of serum concentrations of neuron-specific enolase (NSE) in patients with prostate cancer (PCa) in order to clarify the possible role of NSE in the diagnosis, management, treatment and monitoring of PCa. A comprehensive search of the recent literature was conducted to find relevant data on the role of NSE in PCa. Two hundred and eighty-two records were revealed, and 19 articles including 1,772 patients with PCa (either confirmed or suspected) were selected. After reviewing the articles, the major result was that elevated serum NSE appears to correlate with prognosis in advanced PCa, particularly in patients with progressive and metastatic castration-resistant PCa. Based on the existing literature, the role of serum NSE in PCa patients should be further evaluated.

Post author correction

Article Type: REVIEW

DOI:10.5301/ijbm.5000286

Authors

Barbara Muoio, Mariarosa Pascale, Enrico Roggero

Article History

Disclosures

Financial support: No grants or funding have been received for this study.
Conflict of interest: The authors declare that they have no conflicts of interest.

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Authors

Affiliations

  • Oncology Unit, Oncology Institute of Southern Switzerland, Bellinzona - Switzerland
  • Barbara Muoio and Mariarosa Pascale contributed equally to this work.

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