In this systematic review, we evaluated the value of serum concentrations of neuron-specific enolase (NSE) in patients with prostate cancer (PCa) in order to clarify the possible role of NSE in the diagnosis, management, treatment and monitoring of PCa. A comprehensive search of the recent literature was conducted to find relevant data on the role of NSE in PCa. Two hundred and eighty-two records were revealed, and 19 articles including 1,772 patients with PCa (either confirmed or suspected) were selected. After reviewing the articles, the major result was that elevated serum NSE appears to correlate with prognosis in advanced PCa, particularly in patients with progressive and metastatic castration-resistant PCa. Based on the existing literature, the role of serum NSE in PCa patients should be further evaluated.
Post author correction
Article Type: REVIEW
AuthorsBarbara Muoio, Mariarosa Pascale, Enrico Roggero
- • Received on 23/02/2017
- • Accepted on 07/06/2017
- • Available online on 02/09/2017
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- Muoio, Barbara [PubMed] [Google Scholar] , * Corresponding Author (firstname.lastname@example.org)
- Pascale, Mariarosa [PubMed] [Google Scholar]
- Roggero, Enrico [PubMed] [Google Scholar]
Oncology Unit, Oncology Institute of Southern Switzerland, Bellinzona - Switzerland
Barbara Muoio and Mariarosa Pascale contributed equally to this work.