Neutrophil to lymphocyte ratio as prognostic indicator for patients with esophageal squamous cell cancer



This study aimed to evaluate the correlation between neutrophil to lymphocyte ratio (NLR) with overall survival (OS) of esophageal squamous cell carcinoma (ESCC) patients.


Records of patients with diagnosed ESCC were reviewed. Leukocyte counts and patients’ characteristics were extracted from their clinical records to calculate NLR. Correlation between NLR and baseline characteristics with overall survival (OS) was then analyzed using Cox regression. The patients were then separated into higher and lower NLR groups according to median NLR. OS was further compared between the 2 groups.


A total of 1281 patients were included in the study. Cox regression analysis showed a significant correlation of NLR with OS of ESCC patients. The median pretreatment NLR was identified as 2.86. Higher NLR was associated with worse prognosis in terms of OS.


Pretreatment NLR is independently associated with OS of ESCC patients. Therefore, NLR may be used as a predictive indicator for pretreatment evaluation and adjustment of treatment regimen.

Post author correction


Article Subject: Prognostic/Predictive Biomarkers & Target Therapy



Guo-Dong Gao, Bo Sun, Xian-Bin Wang, Shi-Meng Wang

Article History


Financial support: None.
Conflict of interest: The authors declare they have no conflict of interest.

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  •  Department of Thoracic Surgery, Jining No. 1 People’s Hospital, Jining, Shangdong Province - PR China
  •  Department of Thoracic Surgery, Heze Municipal Hospital, Heze, Shangdong Province - PR China
  • Guo-Dong Gao and Bo Sun contributed equally to this study and are listed as joint first authors.

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