High-risk patients with stage II colon cancer may benefit from adjuvant chemotherapy, but identifying this patient population can be difficult. We assessed the prognosis value for predicting tumor progression in patients with stage II colon cancer, of a panel of 2 biomarkers for colon cancer: tumor budding and preoperative carcinoembryonic antigen (CEA).
Consecutive patients (N = 134) with stage II colon cancer who underwent curative surgery from 2000 to 2007 were included. Multivariate analysis was used to evaluate the association of CEA and tumor budding grade with 5-year disease-free survival (DFS). The prognostic accuracy of CEA, tumor budding grade and the combination of both (CEA-budding panel) was determined.
The study found that both CEA and tumor budding grade were associated with 5-year DFS. The prognostic accuracy for disease progression was higher for the CEA-budding panel (82.1%) than either CEA (70.9%) or tumor budding grade (72.4%) alone.
The findings indicate that the combination of CEA levels and tumor budding grade has greater prognostic value for identifying patients with stage II colon cancer who are at high-risk for disease progression, than either marker alone.
Int J Biol Markers 2017; 32(3): e267 - e273
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsChangzheng Du, Weicheng Xue, Fangyuan Dou, Yifan Peng, Yunfeng Yao, Jun Zhao, Jin Gu
- • Received on 08/09/2016
- • Accepted on 09/02/2017
- • Available online on 05/05/2017
- • Published online on 24/07/2017
This article is available as full text PDF.
- Du, Changzheng [PubMed] [Google Scholar] 1
- Xue, Weicheng [PubMed] [Google Scholar] 2
- Dou, Fangyuan [PubMed] [Google Scholar] 2
- Peng, Yifan [PubMed] [Google Scholar] 1
- Yao, Yunfeng [PubMed] [Google Scholar] 1
- Zhao, Jun [PubMed] [Google Scholar] 1
- Gu, Jin [PubMed] [Google Scholar] 1, * Corresponding Author (zIgujin@126.com)
Department of Gastroenterology Center, Peking University Cancer Hospital, Beijing - PR China
Department of Pathology, Peking University Cancer Hospital, Beijing - PR China
Changzheng Du and Weicheng Xue contributed equally to this work.