IQGAP1 silencing suppresses the malignant characteristics of laryngeal squamous cell carcinoma cells
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Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsXiaoxia Wang, Chun He, Chaohui Li, Benhong Ren, Qing Deng, Wei Gao, Binquan Wang
Laryngeal squamous cell carcinoma (LSCC) has a poor prognosis due to recurrence and metastasis. IQ-domain GTPase-activating protein 1 (IQGAP1), a scaffold protein, plays an important role in tumorigenesis and malignant development. In this study, we aimed to explore the role of IQGAP1 in LSCC.
Expression of IQGAP1 in human LSCC specimens was assessed by immunohistochemistry. We also evaluated the roles of IQGAP1 in cell proliferation, migration and invasion and epithelial-to-mesenchymal transition (EMT) in Hep-2 cells.
The expression of IQGAP1 protein was significantly up-regulated in LSCC tissues compared with normal laryngeal tissues (p = 0.002). Furthermore, the knockdown of IQGAP1 in Hep-2 cells inhibited cell growth, migration and invasion. Moreover, we found that IQGAP1 silencing reversed EMT.
These results show for the first time that IQGAP1 is up-regulated in LSCC tissues and plays an important role in LSCC cell proliferation and invasiveness, which indicates that IQGAP1 could work as an oncogene and may serve as a promising molecular target for treatment of LSCC.
- • Received on 17/04/2017
- • Accepted on 07/06/2017
- • Available online on 08/07/2017
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- Wang, Xiaoxia [PubMed] [Google Scholar] 1, 2, 3, * Corresponding Author (email@example.com)
- He, Chun [PubMed] [Google Scholar] 3
- Li, Chaohui [PubMed] [Google Scholar] 3
- Ren, Benhong [PubMed] [Google Scholar] 3
- Deng, Qing [PubMed] [Google Scholar] 3
- Gao, Wei [PubMed] [Google Scholar] 1, 2
- Wang, Binquan [PubMed] [Google Scholar] 1, 2, * Corresponding Author (firstname.lastname@example.org)
Department of Otolaryngology, Head and Neck Surgery, The First Hospital, Shanxi Medical University, Taiyuan - PR China
Department of Otolaryngology, Head and Neck tumor key Laboratory of Shanxi Province, Shanxi Medical University, Taiyuan - PR China
Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan - PR China