An Increasing number of studies in the literature have shown that microRNAs (miRNAs) can be used as early diagnostic markers for esophageal carcinoma (EC), but their conclusions remain controversial. Hence, we performed this meta-analysis to evaluate the diagnostic accuracy of using miRNAs in EC and to provide an experimental basis for early diagnosis of the disease.
This meta-analysis included 39 Asian studies from 18 articles, which covered 3,708 EC patients and 2,689 healthy controls. We used a bivariate random-effects model, the chi-square test and the I² test to assess sensitivity and heterogeneity.
Pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio of miRNAs for diagnosis of EC in Asians reached 0.798, 0.785, 3.705, 0.257 and 14.391, respectively. Additionally, the area under the summary receiver operating characteristic curve was 0.86. Subgroup analysis based on research country (China vs. Japan), sample types (plasma vs. serum) and miRNAs (single vs. multiple; singly reported miRNAs vs. repeatedly reported miRNAs) showed no significant difference in accuracy of diagnosis for each subgroup.
MiRNAs can distinguish EC patients from healthy controls. Blood-based miRNAs have better diagnostic value in detecting EC than saliva-based miRNAs, whereas both serum and plasma are recommended for clinical specimens for miRNA detection.
Int J Biol Markers 2017; 32(4): e375 - e383
Article Type: REVIEW
AuthorsMei Li, Fei Wu, Yu Ji, Lan Yang, Feng Li
- • Received on 16/02/2017
- • Accepted on 10/07/2017
- • Available online on 28/08/2017
- • Published online on 31/10/2017
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- Li, Mei [PubMed] [Google Scholar] 1
- Wu, Fei [PubMed] [Google Scholar] 1
- Ji, Yu [PubMed] [Google Scholar] 1
- Yang, Lan [PubMed] [Google Scholar] 1, * Corresponding Author (firstname.lastname@example.org)
- Li, Feng [PubMed] [Google Scholar] 1, 2, * Corresponding Author (email@example.com)
Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang - PR China
Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing - PR China
Mei Li and Fei Wu contributed equally to this work.