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Meta-analysis of microRNAs as potential biomarkers for detecting esophageal carcinoma in Asian populations

Abstract

Background:

An Increasing number of studies in the literature have shown that microRNAs (miRNAs) can be used as early diagnostic markers for esophageal carcinoma (EC), but their conclusions remain controversial. Hence, we performed this meta-analysis to evaluate the diagnostic accuracy of using miRNAs in EC and to provide an experimental basis for early diagnosis of the disease.

Methods:

This meta-analysis included 39 Asian studies from 18 articles, which covered 3,708 EC patients and 2,689 healthy controls. We used a bivariate random-effects model, the chi-square test and the I² test to assess sensitivity and heterogeneity.

Results:

Pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio of miRNAs for diagnosis of EC in Asians reached 0.798, 0.785, 3.705, 0.257 and 14.391, respectively. Additionally, the area under the summary receiver operating characteristic curve was 0.86. Subgroup analysis based on research country (China vs. Japan), sample types (plasma vs. serum) and miRNAs (single vs. multiple; singly reported miRNAs vs. repeatedly reported miRNAs) showed no significant difference in accuracy of diagnosis for each subgroup.

Conclusions:

MiRNAs can distinguish EC patients from healthy controls. Blood-based miRNAs have better diagnostic value in detecting EC than saliva-based miRNAs, whereas both serum and plasma are recommended for clinical specimens for miRNA detection.

Int J Biol Markers 2017; 32(4): e375 - e383

Article Type: REVIEW

DOI:10.5301/ijbm.5000296

Authors

Mei Li, Fei Wu, Yu Ji, Lan Yang, Feng Li

Article History

Disclosures

Financial support: This research was supported in part by the National Natural Science Foundation of China (grant nos. 81260301 and 81560399).
Conflict of interest: The authors declare that they have no competing interests.

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Authors

Affiliations

  • Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang - PR China
  • Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing - PR China
  • Mei Li and Fei Wu contributed equally to this work.

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