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PSMB5 is associated with proliferation and drug resistance in triple-negative breast cancer

PSMB5 is associated with proliferation and drug resistance in triple-negative breast cancer

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Article Type: ORIGINAL RESEARCH ARTICLE

Article Subject: Prognostic/Predictive Biomarkers & Target Therapy

DOI:10.5301/ijbm.5000283

Authors

Wensong Wei, Yufeng Zou, Qihua Jiang, Zhibin Zhou, Haolong Ding, Liping Yan, Shixin Yang

Abstract

Background

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, characterized by advanced disease stage and poor prognosis. Moreover, due to the lack of therapeutic markers, TNBC patients can't benefit fully from currently available targeted therapies.

Methods

To fully understand the molecular basis of TNBC, we used gene set enrichment analysis (GSEA) to screen out the most altered functional module in TNBC, from publicly available microarray data and studied the association of the candidate gene with TNBC development.

Results

We found that the proteasome was significantly activated in TNBC. As compared with other breast cancer subtypes and normal tissue, proteasome subunit beta 5 (PSMB5), the key regulator of proteasome function, was overexpressed in TNBC tissue and predictive of poor prognosis. Moreover, we also found that PSMB5 knockdown induced TNBC apoptosis and significantly enhanced cancer cell sensitivity to the chemotherapeutic agents bortezomib and paclitaxel.

Conclusions

Our results suggest a potential role for PSMB5 as a biomarker and therapeutic target for TNBC.

Article History

Disclosures

Financial support: No grants or funding have been received for this study.
Conflict of interest: The authors declare that they have no conflicts of interest.

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Authors

Affiliations

  • Department of Breast Cancer, The Third Hospital of Nanchang City, Nanchang, Jiangxi - PR China

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