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The role of MDM4 SNP34091 A>C polymorphism in cancer: a meta-analysis on 19,328 patients and 51,058 controls

The role of MDM4 SNP34091 A>C polymorphism in cancer: a meta-analysis on 19,328 patients and 51,058 controls

Int J Biol Markers 2017; 32(1): e62 - e67

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/jbm.5000228

Authors

Xin Jin, Wenchao Zhao, Minghua Zheng, Peng Zhou, Tianli Niu

Abstract

Background

Cancer is one of the leading causes of death in the world. Several observational studies have suggested a significant association of the MDM4 SNP34091 A>C polymorphism with cancers. However, the results of the published studies are inconsistent.

Materials and methods

PubMed, Embase/Ovid and the Chinese National Knowledge Infrastructure were searched for relevant studies with a time limit of April 20, 2016. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of the association between MDM4 polymorphism and cancer risk. Publication bias was estimated using Begg’s funnel plots and Egger’s regression test.

Results

A total of 19,328 patients and 51,058 controls were included in the analysis. Overall, a significantly decreased risk of cancer was associated with MDM4 SNP34091 polymorphism for the allele model (C vs. A, OR = 0.715, 95% CI: 0.622-0.821, p = 0.000), dominant model (CC + AC vs. AA, OR = 0.684, 95% CI: 0.563-0.831, p = 0.000), recessive model (CC vs. AC + AA, OR = 1.139, 95% CI = 1.055-1.230, p = 0.001) and heterozygote model (AC vs. AA, OR = 0.687, 95% CI = 0.568-0.832). In the subgroup analysis by cancer type, no significant association was found in the breast cancer subgroup. In the subgroup analysis by geographical region, 2 genetic models, the allele and heterozygote models, showed a significant association in Chinese populations.

Conclusions

The results of our meta-analysis showed that the MDM4 SNP34091 A>C polymorphism may function as a protective factor against cancer risk.

Article History

Disclosures

Financial support: None.
Conflict of interest: The authors declare that there is no conflict of interest regarding the publication of this paper.

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Authors

Affiliations

  • Department of Urology, The Affiliated Taizhou People’s Hospital of Nantong University, Taizhou, Jiangsu - China
  • Xin Jin, Wenchao Zhao and Minghua Zheng contributed equally to this work.

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