High copy number of mitochondrial DNA predicts poor prognosis in patients with advanced stage colon cancer
Int J Biol Markers 2016; 31(4): e382 - e388
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsYun Wang, Shuixiang He, Xingmei Zhu, Wei Qiao, Juan Zhang
The aim of this investigation was to determine whether alterations in mitochondrial DNA (mtDNA) copy number in colon cancer were associated with clinicopathological parameters and postsurgical outcome.
By quantitative real-time PCR assay, the mtDNA copy number was detected in a cohort of colon cancer and matched adjacent colon tissues (n = 162).
The majority of patients had higher mtDNA content in colon cancer tissues than matched adjacent colon tissues. Moreover, high mtDNA content in tumor tissues was associated with larger tumor size, higher serum CEA level, advanced TNM stage, vascular emboli, and liver metastases. Further survival curve analysis showed that high mtDNA content was related to the worst survival in patients with colon cancer at advanced TNM stage.
High mtDNA content is a potential effective factor of poor prognosis in patients with advanced stage colon cancer.
- • Received on 12/02/2016
- • Accepted on 19/04/2016
- • Available online on 17/05/2016
- • Published online on 23/12/2016
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- Wang, Yun [PubMed] [Google Scholar] 1
- He, Shuixiang [PubMed] [Google Scholar] 1, * Corresponding Author (firstname.lastname@example.org)
- Zhu, Xingmei [PubMed] [Google Scholar] 2
- Qiao, Wei [PubMed] [Google Scholar] 3
- Zhang, Juan [PubMed] [Google Scholar] 1
Department of Gastroenterology and Hepatology, the First Hospital of Xian Jiaotong University, Xian - China
College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang - China
Department of Gastroenterology and Hepatology, Ordnance Industry 521 Hospital, Xian - China