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High copy number of mitochondrial DNA predicts poor prognosis in patients with advanced stage colon cancer

High copy number of mitochondrial DNA predicts poor prognosis in patients with advanced stage colon cancer

Int J Biol Markers 2016; 31(4): e382 - e388

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/jbm.5000211

Authors

Yun Wang, Shuixiang He, Xingmei Zhu, Wei Qiao, Juan Zhang

Abstract

Introduction

The aim of this investigation was to determine whether alterations in mitochondrial DNA (mtDNA) copy number in colon cancer were associated with clinicopathological parameters and postsurgical outcome.

Methods

By quantitative real-time PCR assay, the mtDNA copy number was detected in a cohort of colon cancer and matched adjacent colon tissues (n = 162).

Results

The majority of patients had higher mtDNA content in colon cancer tissues than matched adjacent colon tissues. Moreover, high mtDNA content in tumor tissues was associated with larger tumor size, higher serum CEA level, advanced TNM stage, vascular emboli, and liver metastases. Further survival curve analysis showed that high mtDNA content was related to the worst survival in patients with colon cancer at advanced TNM stage.

Conclusions

High mtDNA content is a potential effective factor of poor prognosis in patients with advanced stage colon cancer.

Article History

Disclosures

Financial support: This investigation was supported by grants from the International Cooperation Program of Shaanxi Province (No. S2014kw428 to Shuixiang He), Key Science and Technology Program of Shaanxi Province (No. 2013JC2-21 to Xingmei Zhu), the National Natural Science Foundation of China (No. 81402186 to Xingmei Zhu), and a special grant from the Education Department of Shaanxi Province (No. 14JK1633 to Xingmei Zhu).
Conflict of interest: None of the authors has any conflict of interest related to this study to disclose.

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Authors

Affiliations

  • Department of Gastroenterology and Hepatology, the First Hospital of Xian Jiaotong University, Xian - China
  • College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang - China
  • Department of Gastroenterology and Hepatology, Ordnance Industry 521 Hospital, Xian - China

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