Human chorionic gonadotropin (hCG) is a peptide hormone which plays an important role during pregnancy. But its impact is not limited to pregnancy; it also influences tumor formation and metastatic outgrowth, especially in endometrial adenocarcinoma and breast cancer. This review summarizes what has been written in the literature about the role of hCG as a tumor marker in these 2 gynecological malignancies and also about the signal transduction pathways in which hCG is involved. HCG can, on the one hand, be a marker for the progression of a malignant disease, and on the other hand, it may be a point for therapeutical intervention, so further research into this molecule would be very much worthwhile.
Post author correction
Article Type: REVIEW
AuthorsAlexandra C. Kölbl, Kristina Schlenk, Nils Behrendt, Ulrich Andergassen
- • Received on 22/03/2017
- • Accepted on 14/06/2017
- • Available online on 25/09/2017
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- Kölbl, Alexandra C. [PubMed] [Google Scholar] , * Corresponding Author (firstname.lastname@example.org)
- Schlenk, Kristina [PubMed] [Google Scholar]
- Behrendt, Nils [PubMed] [Google Scholar]
- Andergassen, Ulrich [PubMed] [Google Scholar]
Department of Gynecology and Obstetrics of LMU Munich, Munich - Germany