The importance of hCG in human endometrial adenocarcinoma and breast cancer


Human chorionic gonadotropin (hCG) is a peptide hormone which plays an important role during pregnancy. But its impact is not limited to pregnancy; it also influences tumor formation and metastatic outgrowth, especially in endometrial adenocarcinoma and breast cancer. This review summarizes what has been written in the literature about the role of hCG as a tumor marker in these 2 gynecological malignancies and also about the signal transduction pathways in which hCG is involved. HCG can, on the one hand, be a marker for the progression of a malignant disease, and on the other hand, it may be a point for therapeutical intervention, so further research into this molecule would be very much worthwhile.

Post author correction

Article Type: REVIEW



Alexandra C. Kölbl, Kristina Schlenk, Nils Behrendt, Ulrich Andergassen

Article History


Financial support: No grants or funding have been received for this study.
Conflict of interest: None of the authors has any financial interest related to this study to disclose.

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  • Department of Gynecology and Obstetrics of LMU Munich, Munich - Germany

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