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Vol. 25 Issue 4 (October-December 2010)

Distribution of a single nucleotide polymorphism of insulin-like growth factor-1 in colorectal cancer patients and its association with mucinous adenocarcinoma

Distribution of a single nucleotide polymorphism of insulin-like growth factor-1 in colorectal cancer patients and its association with mucinous adenocarcinoma

Int J Biol Markers 2010; 25(4): 195 - 199

Article Type: ORIGINAL ARTICLE

Authors

Jen-Kou Lin, Ming-Yin Shen, Tzu-Chen Lin, Yuan-Tzu Lan, Huann-Sheng Wang, Shung-Haur Yang, Anna Fen-Yau Li, Shih-Ching Chang

Abstract

Purpose: To analyze the difference in the distribution of an insulin growth factor-1 (IGF-1) polymorphism (-2995 C/A) between young and old colorectal cancer (CRC) patients. Methods: Information from 950 CRC patients undergoing surgery at the Taipei Veterans General Hospital between 2000 and 2005 was collected. The IGF-1 polymorphism was analyzed in patients in extreme age ranges at the time of CRC onset (i.e., under the 20th and above the 80th percentiles, respectively). Associations between clinicopathological variables and the IGF-1 polymorphism were analyzed. Results: Young CRC patients had a higher frequency of advanced disease (58.7%) and mucinous adenocarcinoma (20%) than old CRC patients. Among old CRC patients, the frequency of the AA genotype of IGF-1 was 12.7% (24/189), which was significantly higher than in young patients (4.2%). Other clinicopathological factors including tumor location, differentiation, lymphovascular invasion, and TNM stage were not associated with the AA genotype of IGF-1. Mucinous differentiation (but not the other clinicopathological factors) was significantly associated with the CA/AA genotype of IGF-1 (39/195). Conclusions: Older patients had a higher frequency of the AA genotype of IGF-1(-2995 C/A), while younger patients more often had advanced disease and mucinous adenocarcinoma.

Article History

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Authors

  • Lin, Jen-Kou [PubMed] [Google Scholar]
    Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang-Ming University, Taipei - Taiwan
  • Shen, Ming-Yin [PubMed] [Google Scholar]
    Department of Surgery, Hsinchu General Hospital, Hsinchu - Taiwan
  • Lin, Tzu-Chen [PubMed] [Google Scholar]
    Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang-Ming University, Taipei - Taiwan
  • Lan, Yuan-Tzu [PubMed] [Google Scholar]
    Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang-Ming University, Taipei - Taiwan
  • Wang, Huann-Sheng [PubMed] [Google Scholar]
    Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang-Ming University, Taipei - Taiwan
  • Yang, Shung-Haur [PubMed] [Google Scholar]
    Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang-Ming University, Taipei - Taiwan
  • Li, Anna Fen-Yau [PubMed] [Google Scholar]
    Department of Pathology, Taipei Veterans General Hospital, National Yang-Ming University, Taipei - Taiwan
  • Chang, Shih-Ching [PubMed] [Google Scholar]
    Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang-Ming University, Taipei - Taiwan

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