To investigate the association of DNMT3B -283T>C polymorphism with the risk of lung or gastric cancer, which was followed by a meta-analysis.
The genotyping of -283T>C was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and was confirmed by sequencing.
The results of this case-control study showed that -283T>C was not associated with the risk of lung or gastric cancer, and further stratified analysis according to age, gender, smoking status, and alcohol status confirmed the present finding. However, data from a meta-analysis in the Asian population revealed a significant association between -283T>C and lung cancer risk in the allelic model (C vs. T: odds ratio [OR] = 1.28, 95% confidence interval [CI], 1.06-1.55, p = 0.01) and two genetic models (CC vs. TC: OR = 1.29, 95% CI, 1.04-1.59, p = 0.02; CC vs. TC + TT: OR = 1.30, 95% CI, 1.06-1.60, p = 0.01).
These results provided evidence that the DNMT3B -283T>C polymorphism might significantly contribute to the lung cancer risk in the Asian population, but not the gastric cancer risk in the Chinese population.
Post author correction
Article Type: ORIGINAL RESEARCH ARTICLE
Article Subject: Cancer Epidemiology Biomarkers
AuthorsXianhong Feng, Jingdong Wang, Xiuli Gu, Jingli Zhang, Xiaolin Li, Zhi Tao, Jiebing Chen, Bifeng Chen
- • Received on 16/06/2017
- • Accepted on 19/09/2017
- • Available online on 12/10/2017
This article is available as full text PDF.
- Feng, Xianhong [PubMed] [Google Scholar] 1
- Wang, Jingdong [PubMed] [Google Scholar] 2
- Gu, Xiuli [PubMed] [Google Scholar] 3
- Zhang, Jingli [PubMed] [Google Scholar] 2
- Li, Xiaolin [PubMed] [Google Scholar] 1
- Tao, Zhi [PubMed] [Google Scholar] 1
- Chen, Jiebing [PubMed] [Google Scholar] 1
- Chen, Bifeng [PubMed] [Google Scholar] 2, * Corresponding Author (firstname.lastname@example.org)
Clinical Laboratory, Wuhan Xinzhou District People’s Hospital, Wuhan - PR China
Department of Biological Science and Technology, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan - PR China
Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan - PR China
Xianhong Feng and Jingdong Wang contributed equally to this study