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Association of DNMT3B -283T>C polymorphism with risk of lung and gastric cancer: a case-control study and a meta-analysis

Abstract

Purpose

To investigate the association of DNMT3B -283T>C polymorphism with the risk of lung or gastric cancer, which was followed by a meta-analysis.

Methods

The genotyping of -283T>C was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and was confirmed by sequencing.

Results

The results of this case-control study showed that -283T>C was not associated with the risk of lung or gastric cancer, and further stratified analysis according to age, gender, smoking status, and alcohol status confirmed the present finding. However, data from a meta-analysis in the Asian population revealed a significant association between -283T>C and lung cancer risk in the allelic model (C vs. T: odds ratio [OR] = 1.28, 95% confidence interval [CI], 1.06-1.55, p = 0.01) and two genetic models (CC vs. TC: OR = 1.29, 95% CI, 1.04-1.59, p = 0.02; CC vs. TC + TT: OR = 1.30, 95% CI, 1.06-1.60, p = 0.01).

Conclusions

These results provided evidence that the DNMT3B -283T>C polymorphism might significantly contribute to the lung cancer risk in the Asian population, but not the gastric cancer risk in the Chinese population.

Post author correction

Article Type: ORIGINAL RESEARCH ARTICLE

Article Subject: Cancer Epidemiology Biomarkers

DOI:10.5301/ijbm.5000306

Authors

Xianhong Feng, Jingdong Wang, Xiuli Gu, Jingli Zhang, Xiaolin Li, Zhi Tao, Jiebing Chen, Bifeng Chen

Article History

Disclosures

Financial support: This work was supported by grants from National Natural Science Foundation of China (81502427 and 21404083), and by the Fundamental Research Funds for the Central Universities (WUT: 2017IVA106).
Conflict of interest: None of the authors has financial interest related to this study to disclose.

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Authors

Affiliations

  • Clinical Laboratory, Wuhan Xinzhou District People’s Hospital, Wuhan - PR China
  • Department of Biological Science and Technology, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan - PR China
  • Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan - PR China
  • Xianhong Feng and Jingdong Wang contributed equally to this study

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