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Vol. 21 Issue 4 (October - December)

Serum ferritin in colorectal cancer patients and its prognostic evaluation

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Serum ferritin in colorectal cancer patients and its prognostic evaluation

Int J Biol Markers 2006; 21(4): 235 - 241

Article Type: ORIGINAL ARTICLE

Authors

M. Lorenzi, B. Lorenzi, R. Vernillo

Abstract

The aim of this study was to investigate the relationship between preoperative serum ferritin levels, clinico-pathological parameters and survival analysis of patients with colorectal cancer. Ninety-four patients (57 males) with a mean age of 65 years (39-87 years) underwent 63 curative and 31 palliative operations. Follow-up was at least 5 years. Patients were categorized with normal (30-215 ng/mL in men and 11-148 ng/mL in women), low, or high serum ferritin lev-els. Prognostic evaluation was undertaken with stratified survival analysis and Coxs regression model. Twenty-nine of the patients (30.9%) had raised ferritin levels and 14 (14.9%) had low values. Comparisons of the survival curves showed sig-nificant differences in stage C disease; specifically, patients with either low or high ferritin levels had a shorter survival than patients with normal levels. Patients who underwent palliative surgery and had high ferritin serum values also had a shorter survival. In multivariate analysis, the variables with a negative effect on survival were stage, serum ferritin levels and age. Our data suggest that patients with advanced colorectal cancer having normal preoperative serum ferritin levels may have a better prognosis, although the prognostic value related to this association requires further investigation.

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